WebAlternative splicing of exon 24 (E24) of the myosin phosphatase regulatory subunit (Mypt1) tunes smooth muscle sensitivity to NO/cGMP-mediated vasorelaxation and thereby controls blood pressure (BP) in otherwise normal mice. This occurs via the toggling in or out of a C-terminal leucine zipper (LZ) … WebMar 14, 2003 · Isoforms of the smooth muscle myosin phosphatase targeting subunit 1 (MYPT1) are generated by cassette-type alternative splicing of exons. Tissue-specific …
Calcium signalling links MYC to NUAK1 Oncogene - Nature
WebNov 6, 2024 · MYPT1 reduction is a pathogenic factor of erectile dysfunction. Tissue-specific expression of myosin phosphatase subunits and isoforms in smooth muscle of mice and humans. Editing of the myosin phosphatase regulatory subunit suppresses angiotensin II induced hypertension via sensitization to nitric oxide mediated vasodilation. WebThe myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta. Arch Biochem Biophys. 2011;510:147–159. [ PubMed] [ Google Scholar] 26. … bata cantik
A bioinformatic and computational study of myosin …
WebAlternative mRNA splicing produces four MYPT1 isoforms, differing by the presence or absence of a central insert and leucine zipper (LZ). The LZ domain of MYPT1 has been shown to be important for PKGIα-mediated activation of MLC phosphatase activity, and changes in LZ+ MYPT1 isoform expression result in changes in the sensitivity of smooth ... Webdependent upon its myosin-targeting subunit (MYPT1). Iso-forms of MYPT1 have been identified, but how they are generated and their relationship to smooth muscle pheno-types is not clear. Cloning of the middle section of chicken and rat MYPT1 genes revealed that each gene gave rise to isoforms by cassette-type alternative splicing of exons. In WebMar 14, 2003 · Abstract Isoforms of the smooth muscle myosin phosphatase targeting subunit 1 (MYPT1) are generated by cassette-type alternative splicing of exons. Tissue … tamara rapozo