Jcog9511

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http://www.jcog.jp/document/9511.htm WebJCOG9511 (phaseIII) 進展型小細胞肺癌（ED-SCLC）に対する塩酸イリノテカン＋シスプラチンとエトポシド＋シスプラチンの第Ⅲ相無作為化比較試験. 研究グループ. ：. 肺がん内科グループ. 研究代表者. ：. 西條長宏. 国立がんセンター中央病院.

Feasibility Study of Carboplatin Plus Irinotecan Treatment for …

WebJCOG9511 trial (2002) showed longer overall survival in Japanese patients treated with cisplatin–irinotecan than in patients treated with cisplatin–etoposide (12·8 months . vs. 9·4 months, p=0·002). 3. However, oncologists in Europe and in the USA did not accept cisplatin–irinotecan as a standard regimen because the results of JCOG9511 ... WebJCOG9511 (phaseIII) 進展型小細胞肺癌（ED-SCLC）に対する塩酸イリノテカン＋シスプラチンとエトポシド＋シスプラチンの第Ⅲ相無作為化比較試験研究グループ chinese restaurants raeford rd fay nc

Etoposide and cisplatin versus irinotecan and cisplatin in patients ...

WebThe New England Journal of Medicine: Research & Review Articles on ... Web1 gen 2014 · The doses of cisplatin were the same as in the previous JCOG trial (JCOG9511) in extensive-stage SCLC. 9 If the leucocyte count decreased to less than 3000 leucocytes per μL or the platelet count fell below 10 5 platelets per μL on the first day of etoposide plus cisplatin or irinotecan plus cisplatin, chemotherapy was withheld until the … Web10 ago 2024 · JCOG previously reported the results of a randomized phase III trial (JCOG9511). They found that irinotecan, an inhibitor of the nuclear enzyme topoisomerase I, could improve OS and PFS when combined with platinum. Nevertheless, a series of studies conducted in America and Europe failed to confirm these positive results … chinese restaurant springfield tn

Results of recent Japanese clinical trials in lung cancer

Webundertook a randomised phase 3 trial9 (JCOG9511) comparing irinotecan plus cisplatin with etoposide plus cisplatin in patients with extensive-stage SCLC. Response and overall survival were signiﬁ cantly better for patients treated with irinotecan than those treated with etoposide. The result prompted us to explore the use of irinotecan The purpose of this study is to confirm the superiority of IP in overall survival over EP as post-operative adjuvant chemotherapy for pathological Stage I–IIIA completely resected pulmonary HGNEC patients. Visualizza altro The primary endpoint is overall survival (OS) in all randomized patients. OS is defined as days from randomization to death from any cause, and it is censored at the last day when the patient is alive. The secondary … Visualizza altro After confirming the eligibility criteria, registration is made by telephone, fax or a web-based system to the JCOG Data Center. Patients are randomized to either arm A (EP) or … Visualizza altro Patients in the EP arm receive four courses of post-operative EP (etoposide, 100 mg/m2/day, Day 1–3; cisplatin 80 mg/m2/day, … Visualizza altro chinese restaurant spring valley caWebIrinotecan and cisplatin versus etoposide and cisplatin in small-cell lung cancer: JCOG 9511. Clin Lung Cancer. 2000 Aug;2 (1):23-4. chinese restaurants powder springs ga

"WebBackground This phase I study evaluated the safety and tolerability, pharmacokinetics and pharmacodynamics, immunogenicity, and antitumor activity of pembrolizumab in Japanese patients with advanced solid tumors. Methods Following an initial dose and a 28-day rest (cycle 1), pembrolizumab was admini … " - Jcog9511

Jcog9511

10.3816/CLC.2002.n.007 10.3816/CLC.2002.n.007 DeepDyve

Webbenefit in JCOG9511. The combination chemotherapy with CPT-11þ VP-16 also shows promising results (Karato et al, 1993; Masuda et al, 1998). It is quite reasonable to investigate the three- Web28 giu 2014 · In terms of treatment for extensive-stage SCLC, IP demonstrated superiority to EP in a randomized controlled trial conducted in Japan (JCOG9511). 17 IP is still considered a standard therapy for extensive-stage SCLC in Japan, although two subsequent randomized controlled trials conducted outside Japan were not able to confirm these …

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http://www.jcog.jp/document/9511.htm Web3 nov 2012 · In the JCOG9511 study , grade 3 to 4 diarrhea occurred in 16.0 % of patients treated with cisplatin plus CPT, whereas there was 8.0 % in the present study. Two patients who developed grade 3 diarrhea were switched to the cisplatin plus etoposide regimen and were able to receive a total of 4 cycles of first-line chemotherapy.

WebHome Printers Home Printers Home Printers. Functional and stylish home photo printers and all-in-ones delivering quality results. Small Office Printers Small Office Printers Small Office Printers. Get productive with a range of small … Web25 mag 2024 · A phase III study showed the superiority of IP to EP in pts with extensive stage SCLC (JCOG9511). Methods: Pts with completely resected HGNEC were randomized in a 1:1 ratio to receive either etoposide (100 mg/m 2 , days 1-3)/cisplatin (80 mg/m 2 , day 1) or irinotecan (60 mg/m 2 , days 1, 8, 15)/cisplatin (60 mg/m 2 , day 1), using the …

Web(JCOG9511). Proc Annu Meet Am Soc Clin Oncol. 2000;19:1887. Abstract. Compared to cisplatin plus etoposide, the current standard approach for extensive-stage small-cell lung cancer,cisplatin and CPT-11 showed a significant improve-ment in median survival (420 days vs 300 days). If these data are con-firmed, cisplatin and CPT-11 may WebClinical and Tranlaional Oncology (2024) 22:245–255 247 1 3 TheuseofthoracicradiotherapyforLS-SCLChasdem-onstratedanimprovementof25–30%ofreductionoflocal

WebDownload scientific diagram Phase III Study of CPT-11/CDD vs VP-16/CDDP in SCLC (JCOG9511). from publication: Progress in treatment of small-cell lung cancer: Role of CPT-11 Small-cell lung ...

Web10 gen 2002 · Background: Irinotecan hydrochloride, a topoisomerase I inhibitor, is effective against small-cell lung cancer. In a phase 2 study of irinotecan plus cisplatin in patients with extensive small-cell lung cancer, there was a high response rate and a promising median survival time. chinese restaurants raymond msWeb験（JCOG9511）が実施4され，生存期間中央値（median overallsurvival；mOS）はPE療法が9.4か月であったのに対しPI療法では12.8か月と有意な延長を認めた．この結果から，国内における標準治療はPI療法であると考えられる．しかしながら，JCOG9511を追試 … grand theft auto trilogy pc upgradeWeb1 ago 2000 · Randomized Phase III Study of Irinotecan (CPT-11) and Cisplatin Versus Etoposide and Cisplatin in Extensive- Disease Small-Cell Lung Cancer: Japan Clinical Oncology Group Study (JCOG9511). K Noda, Y Nishiwaki, M Kawahara, S Negoro, T Sugiura, A Yokoyama, M Fukuoka, K Mori, K Watanabe, T Tamura, N Saijo, K … chinese restaurants ravenswood wvWeb13 dic 2013 · In contrast, the dose intensity of irinotecan (60 mg/m 2, Days 1, 8 and 15, every 4 weeks) was 45 mg/m 2 /week in JCOG9511. However, the omission of Day 15 irinotecan occurred in 50% of the courses in JCOG9511 . grand theft auto trilogy pc steamWebWe thank Nobuyuki Horita and colleagues for their interest in the updated results of the CASPIAN trial.1 We believe that the platinum–etoposide chemotherapy regimen used in CASPIAN was appropriate. Major oncological treatment guidelines worldwide recommend either cisplatin or carboplatin, combined with etoposide, as the standard first-line … chinese restaurants rancho cucamonga caWeb3 beds, 1.5 baths, 1054 sq. ft. condo located at 8911G N 95th St, Milwaukee, WI 53224. View sales history, tax history, home value estimates, and overhead views. APN 0340607000. chinese restaurants rathdowne street carltonWebThe results of JCOG9511 have recently been reported; and demonstrated that treatment with irinotecan/cisplatin significantly improved patient survival in extensive-stage small-cell lung cancer over standard etoposide/cisplatin, with less myelosuppression. grand theft auto trilogy price ps5