Irf4 pathway
IRF4 is an essential regulatory component at various stages of B cell development. In early B cell development, IRF4 functions alongside IRF8 to induce the expression of the Ikaros and Aiolos transcription factors, which decrease expression of the pre-B-cell-receptor. [9] See more Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of … See more IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive … See more IRF4 has been shown to interact with: • Aiolos, • BATF3, • Blimp-1, See more • FactorBook IRF4 • IRF4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article … See more In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. A … See more • Interferon regulatory factors See more • Mamane Y, Sharma S, Grandvaux N, Hernandez E, Hiscott J (January 2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis". Journal of Interferon & Cytokine Research. 22 (1): 135–143. doi:10.1089/107999002753452746. PMID 11846984 See more WebApr 4, 2024 · IRF4 Gene Expression on the Trail of Molecular Response: Looking at Chronic Myeloid Leukemia from Another Perspective. Interferon Regulatory Factor 4 (IRF4) …
Irf4 pathway
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WebNov 7, 2016 · IRF4 is a quintessential ‘context-dependent’ factor that regulates unique targets in different contexts in cooperation with different co-regulators. 32, 34 We have identified B cell Integration... WebApr 29, 2014 · IRF4 is composed of a single polypeptide chain containing two independent structural domains, a DNA-binding domain (DBD) and a regulatory domain (RD), which are separated by a flexible linker 11. The N-terminal DBD is highly conserved among IRFs.
WebJul 16, 2024 · Foxp3-expressing regulatory T (Treg) cells can suppress the activity of various types of immune cells and play key roles in the maintenance of self-tolerance and in the regulation of immune responses against pathogens and tumor cells. Treg cells consist of heterogeneous subsets that have distinct phenotypes and functions. Upon antigen … WebJun 1, 2016 · IRF4 siRNA transfection alters baicalin-induced macrophage subtype distribution. IRF4 siRNAs were transfected into mouse peritoneal macrophages. After 6 h, …
WebIRF4 is one of only 2 genes, along with tyrosinase ( TYR ), known to affect the skin, eye, hair, and together with the melanocortin 1 receptor ( MC1R ), freckling. IRF4 independently affects total body naevus counts [4]. IRF4 is predominantly expressed in blood cells with key roles in lymphoid, myeloid and dendritic cell lineages and adipocytes. WebJul 7, 2011 · We have shown that IG/IRF4 fusions are recurrent genetic changes in GC-derived lymphomas and identify a previously unrecognized subset of B-cell lymphomas with characteristic clinical, morphologic, immunophenotypic, and gene expression profiles.
WebApr 11, 2024 · 多人被撤销基金项目！. 国家基金委公布一批科研不端案件处理结果. 2024-04-11 21:49:00 来源: 材料科学与工程 北京 举报. 371. 分享至. 2024年查处的不端行为案件处理结果通报（第一批次）. 近期，经国家自然科学基金委员会监督委员会调查审议、国家自然科学 …
WebFurther studies are required to elucidate the potential association between IRF4 expression and other inflammatory signaling pathways. In conclusion, our results indicate that IRF4 deficiency drives macrophage polarization toward M1 phenotype and increases the production of pro-inflammatory cytokines, which finally results in worsen ... ray ban for prescription framesWebIRF4. Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, [5] [6] [7] located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8] [9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B ... rayban for sale cheapWebIRF8 and IRF4 are also involved in the regulation of B and T-cell development at multiple stages. IRF8 and IRF4 function redundantly to drive common lymphoid progenitors (CLPs) to B-cell lineage. IRF8 and IRF4 are also required in the regulation of germinal center (GC) B cell differentiation. Role in Diseases [ edit] ray-ban for kids sunglassesWebMay 14, 2015 · IRF4 is transcriptionally regulated by the alternative NF-κB pathway (RelB/p52), augmented in some cases by the intronic IRF4 SNP rs12203592-T. IRF4 CNAs are associated with IRF4 protein expression, but their contribution to IRF4 transcription is not known. IRF4 drives Myc expression and tumor proliferation. ray ban frame manufacturerWebMay 25, 2024 · DUSP22-IRF4, fusion in small subset of LyP ( 5%), small and epidermotropic lymphocytes associated with large neoplastic cells in the dermis (CD4- CD8+ or CD4- CD8 … ray ban for women saleWebIRF8 and IRF4 are also involved in the regulation of B and T-cell development at multiple stages. IRF8 and IRF4 function redundantly to drive common lymphoid progenitors (CLPs) … ray ban for mens aviatorWebApr 12, 2024 · 国家自然基金委通报今年首批八起学术不端案件，七起涉“医”. 4月11日，国家自然科学基金委员会官网通报了2024年查处的不端行为案件第一批次8个案件的处理结果。. 因涉嫌买卖实验数据、伪造实验数据、擅自标注基金项目、未经同意使用他人署名、伪造他人 … simple past was were wordwall