Dhhc2 and metabolomics
WebOct 2, 2015 · The interplay between the Apicomplexan parasite Toxoplasma gondii and its host has been largely studied. However, molecular changes at the metabolic level in the …
Dhhc2 and metabolomics
Did you know?
WebNov 3, 2015 · We analysed dhhc2 (PBANKA_010830) transcriptional patterns by semi-quantitative RT-PCR using cDNA prepared from blood and mosquito stage parasites; compared to the control transcripts of hsp70 and 18S ribosomal RNA, we found dhhc2 to be highly transcribed in asexual blood stage parasites and in gametocytes, while mRNA … WebJan 14, 2015 · Importantly, expression of a palmitoylation-independent lipidated AKAP mutant in DHHC2-deficient neurons largely restored normal plasticity regulation. Thus, we conclude that DHHC2-AKAP79/150 …
WebJan 14, 2015 · Having established DHHC2 as a critical regulator of AMPAR synaptic function, we next investigated whether DHHC2 also controls spine structural plasticity … WebPubMed
WebFeb 7, 2024 · Recent research has shown that the metabolomics based on proton nuclear magnetic resonance (1H-NMR) is an accurate, noninvasive and rapid way to diagnose coronary heart disease and its severity 16 ... Webengineering strains are needed. Recently, metabolomics has provided an method to understand better compli-cated microbial metabolism.7) Variation in metabolites is the terminal response in the transmission of bio-information, and thus metabolomics can provide real biological endpoints in omics technology.8) A number of
WebBackground: The substrates and regulation of DHHC protein palmitoyl acyltransferases (PATs) are largely unknown.Results: Flotillin-2 palmitoylation is abolished in DHHC5 gene-targeted neural stem cells, and neuronal differentiation induces DHHC5 turnover.Conclusion: Flotillin-2 is a substrate for DHHC5, which is regulated at the …
WebOct 17, 2024 · Untargeted metabolomics profiling technologies such as high-resolution nuclear magnetic resonance spectroscopy and mass spectrometry (MS) have been used … how to set up an egg incubator arkWebApr 16, 2024 · Metabolomics is the large-scale study of metabolites within cells, biofluids, tissues, or organisms. As such, metabolomics detects systemic fluctuations of multiple … how to set up an ebenefits accountWebOf 12 PATs tested, DAT palmitoylation was stimulated by DHHC2, DHHC3, DHHC8, DHHC15, and DHHC17, with others having no effect. Increased modification was localized to previously identified palmitoylation site Cys580 and resulted in upregulation of transport kinetics and elevated transporter expression mediated by reduced degradation. nothelfer zofingenWebDHHC2 is found primarily in dendrites or within PSDs (9, 23, 31). It palmitoylates PSD95 while in PSDs, and 2-BP acts largely by blocking DHHC2 in PSDs , allowing the unidentified PPT in PSDs to dominate … nothelfer wohnmobile rottweilWebDec 26, 2024 · Metabolomics revealed alterations in different metabolites (mainly sphingolipids and glycerophospholipids) in cells overexpressing TDP-43. Our data reveal the main role of TDP-43 aggregation in cellular death and highlight novel insight into the mechanism of cellular toxicity induced by TDP-43. Here, we provide a simple, sensitive, … nothelfer-online.chWebmetabolomics technology and analysis. Additionally, I express my gratitude to Dr Khalid Saqib for introducing me to the main techniques in the lab and to Dr Iwona Bujalska for her helpful discussion, guidance with writing this thesis and friendship. I would like to thank the past and present colleagues and friends on the 2nd floor nothelfer wohnmobileWebOct 5, 2015 · Mass spectrometry (MS)-based metabolomics allow the concomitant detection of several hundred metabolites as a snapshot of metabolomics phenomena (Sawada et al. 2009). Integrated metabolomics, genomics, and transcriptomics, referred to as omics technologies , play an important role in phytochemical genomic and crop … how to set up an echolink node