WebRCSM. RCSM(Recommended Connectivity-map Scoring Methods) Description. Connecting disease gene expression signatures to compound-induced gene expression profiles is valuable for understanding drug Mechanism of Action (MoA) and applying an existing therapeutic to a new disease indication. RCSM is an R package for measuring … WebOct 9, 2024 · Methods: RCSM is an iterative method that includes three steps per cycle: (1) identify and prioritize stakeholder questions, (2) develop or refine a simulation model, and (3) engage in dialogue regarding model relevance, insights, and utility for implementation. For the case study, 31 key informants were engaged in step 1, a prior simulation ...
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